Beta-catenin: The Key Regulator of Wnt Signaling Transcription

What is an important regulator of transcription downstream of Wnt signaling?

Final answer:

Beta-catenin regulates transcription downstream of Wnt signaling. It accumulates in the cell after Wnt proteins bind to cell surface receptors, and then stimulates the transcription of Wnt target genes in the nucleus.

Explanation:

The best answer to complete the statement: 'Beta-catenin is an important regulator of transcription downstream of Wnt signaling' is option 'd. Beta-catenin'. This protein plays a pivotal role in the Wnt signaling pathway. Wnt proteins bind to receptors on the cell surface, which stops the degradation of Beta-catenin. As a result, Beta-catenin accumulates in the cell. Finally, Beta-catenin moves into the nucleus where it stimulates the transcription of Wnt target genes. Therefore, Beta-catenin is an essential regulator of transcription that is downstream of Wnt signaling.

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