Understanding the G2 Checkpoint in Cell Division

Which checkpoint ensures DNA is properly replicated prior to division, and initiates apoptosis if DNA repair is unsuccessful?

O S Checkpoint

O M Checkpoint

O G Checkpoint

O G2 Checkpoint

Answer:

The G2 checkpoint ensures proper DNA replication prior to division and triggers apoptosis in case of unsuccessful DNA repair.

The G2 checkpoint is a critical stage in the cell cycle that ensures the accurate replication of DNA before the cell proceeds to division. This checkpoint plays a key role in maintaining genomic integrity by checking for any DNA damage or incomplete replication that may have occurred during the process.

If the cell detects any abnormalities or errors in DNA replication at the G2 checkpoint, it will trigger apoptosis, which is a programmed cell death mechanism. Apoptosis serves as a safeguard mechanism to eliminate cells with damaged DNA that could potentially lead to mutations or cancer if allowed to divide.

By halting the cell cycle at the G2 checkpoint and initiating apoptosis when needed, the cell ensures that only genetically stable and healthy cells proceed to division, thereby maintaining overall cellular health and function.