Understanding Lymphomatoid Papulosis (LyP)

What condition presents as crops of papules that can ulcerate, CD30+ T cells, is benign but increased risk of lymphoma?

A. Keratosis pilaris

B. Lymphomatoid papulosis (LyP)

C. Psoriasis

D. Eczema

E. Acne vulgaris

Answer:

The correct answer is B. Lymphomatoid papulosis (LyP).

Lymphomatoid papulosis (LyP) is a skin condition characterized by crops of papules that may ulcerate and involve CD30+ T cells. While LyP is considered benign, individuals diagnosed with this condition have an increased risk of developing lymphoma.

LyP is classified as a primary cutaneous CD30+ lymphoproliferative disorder. It is chronic, recurrent, and often self-healing, but regular monitoring is essential due to the potential for the condition to progress into a more serious lymphoma, such as Hodgkin lymphoma or anaplastic large cell lymphoma.

Patients with LyP should receive close medical supervision to detect any signs of lymphoma development early. The rapid growth of lesions throughout the body should raise concerns about immune system compromise or aggressive cancer types like Kaposi's sarcoma or Burkitt lymphoma, which differ from the typical course of LyP.